Cardiac hypertrophy is characterized by a generalized increase in gene expression that is
commensurate with the increase in myocyte size and mass, on which is superimposed more
robust changes in the expression of specialized genes. Both transcriptional and
posttranscriptional mechanisms play fundamental roles in these processes; however,
genome-wide characterization of the transcriptional changes has not been investigated. Our
goal was to identify the extent and modes, RNA polymerase II (pol II) pausing versus …