[HTML][HTML] Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels
C Wang, C Wang, EG Hoch, GS Pitt - Journal of Biological Chemistry, 2011 - ASBMB
Fibroblast growth factor homologous factors (FHFs, FGF11–14) bind to the C termini (CTs) of
specific voltage-gated sodium channels (VGSC) and thereby regulate their function. The
effect of an individual FHF on a specific VGSC varies greatly depending upon the individual
FHF isoform. How individual FHFs impart distinctive effects on specific VGSCs is not known
and the specificity of these pairwise interactions is not understood. Using several
biochemical approaches combined with functional analysis, we mapped the interaction site …
specific voltage-gated sodium channels (VGSC) and thereby regulate their function. The
effect of an individual FHF on a specific VGSC varies greatly depending upon the individual
FHF isoform. How individual FHFs impart distinctive effects on specific VGSCs is not known
and the specificity of these pairwise interactions is not understood. Using several
biochemical approaches combined with functional analysis, we mapped the interaction site …