Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice
Biochemical and biophysical research communications, 2007•Elsevier
The Cardiac sodium channel gene SCN5A plays a critical role in cardiac electrophysiology
and its mutations, either gain-or loss-of-functions, are associated with lethal arrhythmias. In
this study, we investigated the effect of overexpression of SCN5A on the cardiac phenotype
in a transgenic mouse model (TG-WT L10). Compared to NTG mice, heart rate, QRS
duration, and QT intervals remained unchanged in TG-WT mice. Moreover, no spontaneous
ventricular arrhythmias were detected in TG-WT hearts. Despite these results, a mild …
and its mutations, either gain-or loss-of-functions, are associated with lethal arrhythmias. In
this study, we investigated the effect of overexpression of SCN5A on the cardiac phenotype
in a transgenic mouse model (TG-WT L10). Compared to NTG mice, heart rate, QRS
duration, and QT intervals remained unchanged in TG-WT mice. Moreover, no spontaneous
ventricular arrhythmias were detected in TG-WT hearts. Despite these results, a mild …
The Cardiac sodium channel gene SCN5A plays a critical role in cardiac electrophysiology and its mutations, either gain- or loss-of-functions, are associated with lethal arrhythmias. In this study, we investigated the effect of overexpression of SCN5A on the cardiac phenotype in a transgenic mouse model (TG-WT L10). Compared to NTG mice, heart rate, QRS duration, and QT intervals remained unchanged in TG-WT mice. Moreover, no spontaneous ventricular arrhythmias were detected in TG-WT hearts. Despite these results, a mild, irregular cardiac phenotype was observed in TG-WT mice. The P wave and PR interval were significantly shorter in TG-WT compared with NTG mice (P, 8.8±0.8ms vs. 12.6±0.9ms; PR, 12.5±2ms vs. 33.5±0.7ms). Furthermore, spontaneous premature atrial contractions were often detected in TG-WT mice. These results suggest that the expression level of the SCN5A gene is a determinant for the length of the P wave duration and PR interval on electrocardiograms (ECG).
Elsevier