Mechanisms of persistent atrial fibrillation
J Jalife - Current opinion in cardiology, 2014 - journals.lww.com
Current opinion in cardiology, 2014•journals.lww.com
Identifying upstream strategies targeting molecular pathways that are common to fibrosis
and electrical remodeling leading to atrial fibrillation perpetuation is highly desirable. This
would facilitate finding new target genes with pleiotropic effects on the expression of ion
channel proteins in myocytes and profibrotic molecules in nonmyocyte cells that are
important for pathologic remodeling, which could become an important goal in persistent
atrial fibrillation therapy.
and electrical remodeling leading to atrial fibrillation perpetuation is highly desirable. This
would facilitate finding new target genes with pleiotropic effects on the expression of ion
channel proteins in myocytes and profibrotic molecules in nonmyocyte cells that are
important for pathologic remodeling, which could become an important goal in persistent
atrial fibrillation therapy.
Summary
Identifying upstream strategies targeting molecular pathways that are common to fibrosis and electrical remodeling leading to atrial fibrillation perpetuation is highly desirable. This would facilitate finding new target genes with pleiotropic effects on the expression of ion channel proteins in myocytes and profibrotic molecules in nonmyocyte cells that are important for pathologic remodeling, which could become an important goal in persistent atrial fibrillation therapy.
Lippincott Williams & Wilkins