Dnmt3a and Dnmt3b are two major de novo DNA methyltransferases essential for
embryonic development in mammals. It has been shown that Dnmt3a and Dnmt3b have
distinct substrate preferences for certain genomic loci, including major and minor satellite
repeats. However, the exact target CpG sites where Dnmt3a and Dnmt3b catalyze DNA
methylation remains largely unknown. To identify a CpG site that is specifically methylated
by Dnmt3a or Dnmt3b, we screened methylated genomic loci by methylation sensitive …