[HTML][HTML] Manipulation of alternative splicing by a newly developed inhibitor of Clks
M Muraki, B Ohkawara, T Hosoya, H Onogi… - Journal of Biological …, 2004 - ASBMB
The regulation of splice site usage provides a versatile mechanism for controlling gene
expression and for the generation of proteome diversity, playing an essential role in many
biological processes. The importance of alternative splicing is further illustrated by the
increasing number of human diseases that have been attributed to mis-splicing events.
Appropriate spatial and temporal generation of splicing variants demands that alternative
splicing be subjected to extensive regulation, similar to transcriptional control. The Clk (Cdc2 …
expression and for the generation of proteome diversity, playing an essential role in many
biological processes. The importance of alternative splicing is further illustrated by the
increasing number of human diseases that have been attributed to mis-splicing events.
Appropriate spatial and temporal generation of splicing variants demands that alternative
splicing be subjected to extensive regulation, similar to transcriptional control. The Clk (Cdc2 …