[HTML][HTML] A novel MDMX transcript expressed in a variety of transformed cell lines encodes a truncated protein with potent p53 repressive activity
R Rallapalli, G Strachan, B Cho, WE Mercer… - Journal of Biological …, 1999 - ASBMB
The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the
p53 tumor suppressor. We have identified a novel transcript of the MDMX gene that is
expressed in a variety of cell lines, and in particular, in growing and transformed cells. This
transcript is identical to the published sequence yet it has a short internal deletion of 68 base
pairs. This deletion produces a shift in the reading frame after codon 114, resulting in the
inclusion of a stop codon at amino acid residue 127 (full-length MDMX is 489 residues). This …
p53 tumor suppressor. We have identified a novel transcript of the MDMX gene that is
expressed in a variety of cell lines, and in particular, in growing and transformed cells. This
transcript is identical to the published sequence yet it has a short internal deletion of 68 base
pairs. This deletion produces a shift in the reading frame after codon 114, resulting in the
inclusion of a stop codon at amino acid residue 127 (full-length MDMX is 489 residues). This …