[HTML][HTML] Hypoxic reactive oxygen species regulate the integrated stress response and cell survival
Under hypoxic conditions, cells suppress energy-intensive mRNA translation by modulating
the mammalian target of rapamycin (mTOR) and pancreatic eIF2α kinase (PERK) pathways.
Much is known about hypoxic inhibition of mTOR activity; however, the cellular processes
activating PERK remain unclear. Since hypoxia is known to increase intracellular reactive
oxygen species (ROS), we hypothesized that hypoxic ROS regulate mTOR and PERK to
control mRNA translation and cell survival. Our data indicate that although exogenous ROS …
the mammalian target of rapamycin (mTOR) and pancreatic eIF2α kinase (PERK) pathways.
Much is known about hypoxic inhibition of mTOR activity; however, the cellular processes
activating PERK remain unclear. Since hypoxia is known to increase intracellular reactive
oxygen species (ROS), we hypothesized that hypoxic ROS regulate mTOR and PERK to
control mRNA translation and cell survival. Our data indicate that although exogenous ROS …