Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial
SRM Dobson, S McNeil, M Dionne, M Dawar, G Ogilvie… - Jama, 2013 - jamanetwork.com
Importance Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer
is impeded by cost. A 2-dose schedule for girls may be possible. Objective To determine
whether mean antibody levels to HPV-16 and HPV-18 among girls receiving 2 doses was
noninferior to women receiving 3 doses. Design, Setting, and Patients Randomized, phase
3, postlicensure, multicenter, age-stratified, noninferiority immunogenicity study of 830
Canadian females from August 2007 through February 2011. Follow-up blood samples were …
is impeded by cost. A 2-dose schedule for girls may be possible. Objective To determine
whether mean antibody levels to HPV-16 and HPV-18 among girls receiving 2 doses was
noninferior to women receiving 3 doses. Design, Setting, and Patients Randomized, phase
3, postlicensure, multicenter, age-stratified, noninferiority immunogenicity study of 830
Canadian females from August 2007 through February 2011. Follow-up blood samples were …