Human papillomavirus infection and the multistage carcinogenesis of cervical cancer

M Schiffman, N Wentzensen - Cancer epidemiology, biomarkers & …, 2013 - AACR
Cancer epidemiology, biomarkers & prevention, 2013AACR
This short review outlines our understanding of cervical cancer precursors, concentrating on
the central etiologic role of persistent human papillomavirus infection. The stages of cervical
carcinogenesis are better understood than for most other major cancers, providing a
successful cancer etiology and prevention model. Cancer Epidemiol Biomarkers Prev; 22
(4); 553–60.© 2013 AACR.
Abstract
This short review outlines our understanding of cervical cancer precursors, concentrating on the central etiologic role of persistent human papillomavirus infection. The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology and prevention model. Cancer Epidemiol Biomarkers Prev; 22(4); 553–60. ©2013 AACR.
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