Up-regulation of programmed cell death 1 ligand 1 on neutrophils may be involved in sepsis-induced immunosuppression: an animal study and a prospective case …
JF Wang, JB Li, YJ Zhao, WJ Yi, JJ Bian, XJ Wan… - …, 2015 - pubs.asahq.org
Background: Recent studies have shown that neutrophils may display an antigen-presenting
function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand
1 (PD-L1). The current study was performed to investigate the effect of neutrophils and their
pathophysiological significance during sepsis. Methods: Neutrophil PD-L1 expression was
determined in both septic mice (n= 6) and patients (n= 41). Neutrophils from septic mice
were subtyped into PD-L1− and PD-L1+ populations to determine their phenotypes and …
function and inhibit lymphocyte proliferation by expressing programmed cell death 1 ligand
1 (PD-L1). The current study was performed to investigate the effect of neutrophils and their
pathophysiological significance during sepsis. Methods: Neutrophil PD-L1 expression was
determined in both septic mice (n= 6) and patients (n= 41). Neutrophils from septic mice
were subtyped into PD-L1− and PD-L1+ populations to determine their phenotypes and …