[HTML][HTML] The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK …
D Gao, S Nong, X Huang, Y Lu, H Zhao, Y Lin… - Journal of Biological …, 2010 - ASBMB
Elevated plasma free fatty acid (FFA) levels in obesity may play a pathogenic role in the
development of insulin resistance. However, molecular mechanisms linking FFA to insulin
resistance remain poorly understood. Oxidative stress acts as a link between FFA and
hepatic insulin resistance. NADPH oxidase 3 (NOX3)-derived reactive oxygen species
(ROS) may mediate the effect of TNF-α on hepatocytes, in particular the drop in cellular
glycogen content. In the present study, we define the critical role of NOX3-derived ROS in …
development of insulin resistance. However, molecular mechanisms linking FFA to insulin
resistance remain poorly understood. Oxidative stress acts as a link between FFA and
hepatic insulin resistance. NADPH oxidase 3 (NOX3)-derived reactive oxygen species
(ROS) may mediate the effect of TNF-α on hepatocytes, in particular the drop in cellular
glycogen content. In the present study, we define the critical role of NOX3-derived ROS in …