[HTML][HTML] The key role of anaplerosis and cataplerosis for citric acid cycle function

OE Owen, SC Kalhan, RW Hanson - Journal of Biological Chemistry, 2002 - ASBMB
The oxidation of acetyl-CoA to CO2 by the TCA1 cycle is the central process in energy
metabolism. However, the TCA cycle also functions in biosynthetic pathways in which
intermediates leave the cycle to be converted primarily to glucose, fatty acids, or non-
essential amino acids. If TCA cycle anions are removed from the cycle they must be
replaced to permit its continued function. This process is termed anaplerosis. Pyruvate
carboxylase, which generates oxalacetate directly in the mitochondria, is the major …