Platelet response as a sentinel marker of toll-like receptor 4 activation in mice
M Jayachandran, VM Miller, GJ Brunn, WG Owen - Thrombosis research, 2010 - Elsevier
Chronic low grade infection with Gram negative organisms, inferred from traces in plasma of
endotoxin, or lipopolysaccharide (LPS), has been linked to ischemic vascular disease [1–3].
Low level bacteremia in nominally healthy individuals may be a normal state involving
commensal organisms and can arise from activities as routine as tooth brushing [4]. Innate
immune responses to Gram negative bacteria involve interaction of bacterial LPS with toll-
like receptor 4 (TLR4), which occurs on the surface of most cells, including platelets [5] …
endotoxin, or lipopolysaccharide (LPS), has been linked to ischemic vascular disease [1–3].
Low level bacteremia in nominally healthy individuals may be a normal state involving
commensal organisms and can arise from activities as routine as tooth brushing [4]. Innate
immune responses to Gram negative bacteria involve interaction of bacterial LPS with toll-
like receptor 4 (TLR4), which occurs on the surface of most cells, including platelets [5] …