Translational control by heme-regulated eIF2α kinase during erythropoiesis
JJ Chen - Current opinion in hematology, 2014 - journals.lww.com
Current opinion in hematology, 2014•journals.lww.com
Summary HRI–eIF2αP–ATF4 stress signaling is important not only to inhibit excess globin
synthesis during erythropoiesis, but is also critical for adaptation to oxidative stress and for
enhancing effective erythropoiesis. Modulation of this signaling pathway with small
chemicals may provide a novel therapy for hemoglobinopathy.
synthesis during erythropoiesis, but is also critical for adaptation to oxidative stress and for
enhancing effective erythropoiesis. Modulation of this signaling pathway with small
chemicals may provide a novel therapy for hemoglobinopathy.
Summary
HRI–eIF2αP–ATF4 stress signaling is important not only to inhibit excess globin synthesis during erythropoiesis, but is also critical for adaptation to oxidative stress and for enhancing effective erythropoiesis. Modulation of this signaling pathway with small chemicals may provide a novel therapy for hemoglobinopathy.
Lippincott Williams & Wilkins