[HTML][HTML] Evidence that the expression of transferrin receptor 1 on erythroid marrow cells mediates hepcidin suppression in the liver
Highlights•Transferrin receptor 1 expression on erythroid precursors may be a proximal
mediator of the erythroid regulator of hepcidin expression.Hepcidin is the key regulator of
iron absorption and recycling, and its expression is suppressed by red blood cell production.
When erythropoiesis is expanded, hepcidin expression decreases. To gain insight into the
stage of erythroid differentiation at which the regulation might originate, we measured serum
hepcidin levels in archived pure red cell aplasia samples from patients whose block in …
mediator of the erythroid regulator of hepcidin expression.Hepcidin is the key regulator of
iron absorption and recycling, and its expression is suppressed by red blood cell production.
When erythropoiesis is expanded, hepcidin expression decreases. To gain insight into the
stage of erythroid differentiation at which the regulation might originate, we measured serum
hepcidin levels in archived pure red cell aplasia samples from patients whose block in …