[HTML][HTML] Chronic immune stimulation might act as a trigger for the development of acute myeloid leukemia or myelodysplastic syndromes

SY Kristinsson, M Björkholm, M Hultcrantz… - Journal of Clinical …, 2011 - ncbi.nlm.nih.gov
SY Kristinsson, M Björkholm, M Hultcrantz, ÅR Derolf, O Landgren, LR Goldin
Journal of Clinical Oncology, 2011ncbi.nlm.nih.gov
Purpose Patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)
often present with infections, but there are little data to assess whether a personal history of
selected infections may act as pathogenic triggers. To additionally expand our knowledge
on the role of immune stimulation in the causation of AML and MDS, we have conducted a
large, population-based study to evaluate the risk of AML and MDS associated with a prior
history of a broad range of infections or autoimmune diseases.
Abstract
Purpose
Patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) often present with infections, but there are little data to assess whether a personal history of selected infections may act as pathogenic triggers. To additionally expand our knowledge on the role of immune stimulation in the causation of AML and MDS, we have conducted a large, population-based study to evaluate the risk of AML and MDS associated with a prior history of a broad range of infections or autoimmune diseases.
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