" Foreign Serum" Heterophile Antibodies in Patients Receiving Antithymocyte Antisera

B Pirofsky, JC Ramirez-Mateos, A August - Blood, 1973 - ashpublications.org
B Pirofsky, JC Ramirez-Mateos, A August
Blood, 1973ashpublications.org
Forty-six patients with venous immunologically mediated or lymphoproliferative diseases
received goat antihuman thymocyte antisera globulin (ATG) therapy. Heterophile antibody
production occurred in 91% of these patients, following ATG administration. The heterophile
antibody was absorbable with both guinea pig kidney and boiled beef erythrocyte antigens.
This corresponds to a form of heterophile antibody previously reported as a" serum
sickness" variety. The heterophile antibody was composed of a mixture of gamma G and …
Abstract
Forty-six patients with venous immunologically mediated or lymphoproliferative diseases received goat antihuman thymocyte antisera globulin (ATG) therapy. Heterophile antibody production occurred in 91 % of these patients, following ATG administration. The heterophile antibody was absorbable with both guinea pig kidney and boiled beef erythrocyte antigens. This corresponds to a form of heterophile antibody previously reported as a "serum sickness" variety. The heterophile antibody was composed of a mixture of gamma G and gamma M antibodies and was partially absorbed by ATG. Serum sickness did not occur in any of these patients, in spite of the production of heterophile antibodies. It is recommended that the involved heterogenetic antigen be termed "foreign serum" variety, and the resulting antibody described as a "foreign serum" type of heterophile antibody.
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