Following trauma there is an early hyper-reactive inflammatory response that can lead to
multiple organ dysfunction and high mortality in trauma patients; this response is often
accompanied by a delayed immunosuppression that adds the clinical complications of
infection and can also increase mortality. 1-9 Many studies have begun to assess these
changes in the reactivity of the immune system following trauma. 10-15 Immunologic studies
are greatly supported through the wide variety of transgenic and knockout mice available for …