Platelets in atherothrombosis
ZM Ruggeri - Nature medicine, 2002 - nature.com
Nature medicine, 2002•nature.com
The participation of platelets in atherogenesis and the subsequent formation of occlusive
thrombi depend on platelets' adhesive properties and the inability to respond to stimuli with
rapid activation. By understanding the multifaceted mechanisms involved in platelet
interactions with vascular surfaces and aggregation, new approaches can be tailored to
selectively inhibit the pathways most relevant to the pathological aspects of
atherothrombosis.
thrombi depend on platelets' adhesive properties and the inability to respond to stimuli with
rapid activation. By understanding the multifaceted mechanisms involved in platelet
interactions with vascular surfaces and aggregation, new approaches can be tailored to
selectively inhibit the pathways most relevant to the pathological aspects of
atherothrombosis.
The participation of platelets in atherogenesis and the subsequent formation of occlusive thrombi depend on platelets' adhesive properties and the inability to respond to stimuli with rapid activation. By understanding the multifaceted mechanisms involved in platelet interactions with vascular surfaces and aggregation, new approaches can be tailored to selectively inhibit the pathways most relevant to the pathological aspects of atherothrombosis.
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