Necrotizing myopathy with pipestem capillaries, microvascular deposition of the complement membrane attack complex (MAC), and minimal cellular infiltration
M Alison, G Andrew - Neurology, 1991 - AAN Enterprises
M Alison, G Andrew
Neurology, 1991•AAN EnterprisesThree adult patients, two with undifferentiated connective tissue disease and one with
carcinoma, had a distinctive pathologic reaction pattern consisting of necrotizing myopathy,
minimal cellular infiltration, and a microangiopathy with thick" pipestem" vessels and
microvascular deposits of complement membrane attack complex. Quantitative analysis
revealed focal capillary depletion. This pattern represents an immune-mediated
microangiopathy and is distinct from that observed in other inflammatory myopathies.
carcinoma, had a distinctive pathologic reaction pattern consisting of necrotizing myopathy,
minimal cellular infiltration, and a microangiopathy with thick" pipestem" vessels and
microvascular deposits of complement membrane attack complex. Quantitative analysis
revealed focal capillary depletion. This pattern represents an immune-mediated
microangiopathy and is distinct from that observed in other inflammatory myopathies.
Three adult patients, two with undifferentiated connective tissue disease and one with carcinoma, had a distinctive pathologic reaction pattern consisting of necrotizing myopathy, minimal cellular infiltration, and a microangiopathy with thick "pipestem" vessels and microvascular deposits of complement membrane attack complex. Quantitative analysis revealed focal capillary depletion. This pattern represents an immune-mediated microangiopathy and is distinct from that observed in other inflammatory myopathies.
American Academy of Neurology