[HTML][HTML] The role of Hsp90N, a new member of the Hsp90 family, in signal transduction and neoplastic transformation
N Grammatikakis, A Vultur, CV Ramana… - Journal of Biological …, 2002 - ASBMB
The 90-kDa heat shock protein (Hsp90), the target of the ansamycin class of anti-cancer
drugs, is required for the conformational activation of a specific group of signal transducers,
including Raf-1. In this report we have identified a 75-kDa Raf-associated protein as
Hsp90N, a novel member of the Hsp90 family. Intriguingly, the ansamycin-binding domain is
replaced in Hsp90N by a much shorter, hydrophobic sequence, preceded by a putative
myristylation signal. We demonstrate that, although much less abundant, Hsp90N binds Raf …
drugs, is required for the conformational activation of a specific group of signal transducers,
including Raf-1. In this report we have identified a 75-kDa Raf-associated protein as
Hsp90N, a novel member of the Hsp90 family. Intriguingly, the ansamycin-binding domain is
replaced in Hsp90N by a much shorter, hydrophobic sequence, preceded by a putative
myristylation signal. We demonstrate that, although much less abundant, Hsp90N binds Raf …