[HTML][HTML] Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott …
T Lhermusier, H Chap, B Payrastre - Journal of Thrombosis and …, 2011 - Elsevier
Like all eukaryotic cells, platelets maintain plasma membrane phospholipid asymmetry in
normal blood circulation via lipid transporters, which control transbilayer movement. Upon
platelet activation, the asymmetric orientation of membrane phospholipids is rapidly
disrupted, resulting in a calcium‐dependent exposure of the anionic phospholipid,
phosphatidylserine (PS), at the outer platelet surface. This newly‐exposed PS surface is a
major component of normal hemostasis because it supports platelet procoagulant function …
normal blood circulation via lipid transporters, which control transbilayer movement. Upon
platelet activation, the asymmetric orientation of membrane phospholipids is rapidly
disrupted, resulting in a calcium‐dependent exposure of the anionic phospholipid,
phosphatidylserine (PS), at the outer platelet surface. This newly‐exposed PS surface is a
major component of normal hemostasis because it supports platelet procoagulant function …