[HTML][HTML] Oleoyl-CoA Is the Major de NovoProduct of Stearoyl-CoA Desaturase 1 Gene Isoform and Substrate for the Biosynthesis of the Harderian Gland 1-Alkyl-2, 3 …
M Miyazaki, HJ Kim, WC Man, JM Ntambi - Journal of Biological Chemistry, 2001 - ASBMB
1-Alkyl-2, 3-diacylglycerol (ADG) is a unique neutral lipid found in the eyeball-associated
Harderian gland (HG) of the mouse and acts as a lubricant to facilitate eyelid movement. We
found that the HG of the mice with a disruption in the gene for stearoyl-CoA desaturase 1
(SCD1)(SCD1−/−) is deficient in ADG. The amount of C20: 1n-9, which is a major fatty acid
of ADG, was reduced by greater than 90% despite normal elongase enzyme activity
proposed to elongate it from C18: 1n-9. HG from SCD1−/− mice exhibited high desaturase …
Harderian gland (HG) of the mouse and acts as a lubricant to facilitate eyelid movement. We
found that the HG of the mice with a disruption in the gene for stearoyl-CoA desaturase 1
(SCD1)(SCD1−/−) is deficient in ADG. The amount of C20: 1n-9, which is a major fatty acid
of ADG, was reduced by greater than 90% despite normal elongase enzyme activity
proposed to elongate it from C18: 1n-9. HG from SCD1−/− mice exhibited high desaturase …