[HTML][HTML] Inhibited insulin signaling in mouse hepatocytes is associated with increased phosphatidic acid but not diacylglycerol
C Zhang, G Hwarng, DE Cooper… - Journal of Biological …, 2015 - ASBMB
Although an elevated triacylglycerol content in non-adipose tissues is often associated with
insulin resistance, the mechanistic relationship remains unclear. The data support roles for
intermediates in the glycerol-3-phosphate pathway of triacylglycerol synthesis:
diacylglycerol (DAG), which may cause insulin resistance in liver by activating PKCϵ, and
phosphatidic acid (PA), which inhibits insulin action in hepatocytes by disrupting the
assembly of mTOR and rictor. To determine whether increases in DAG and PA impair insulin …
insulin resistance, the mechanistic relationship remains unclear. The data support roles for
intermediates in the glycerol-3-phosphate pathway of triacylglycerol synthesis:
diacylglycerol (DAG), which may cause insulin resistance in liver by activating PKCϵ, and
phosphatidic acid (PA), which inhibits insulin action in hepatocytes by disrupting the
assembly of mTOR and rictor. To determine whether increases in DAG and PA impair insulin …