[HTML][HTML] Activating transcription factor 4 regulates stearate-induced vascular calcification
M Masuda, TC Ting, M Levi, SJ Saunders… - Journal of lipid …, 2012 - ASBMB
Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic
differentiation and mineralization of vascular smooth muscle cells (VSMC). In this study, we
examined the molecular mechanisms by which stearate promotes vascular calcification.
ATF4 is a pivotal transcription factor in osteoblastogenesis and endoplasmic reticulum (ER)
stress. Increased stearate by either supplementation of exogenous stearic acid or inhibition
of stearoyl-CoA desaturase (SCD) by CAY10566 induced ATF4 mRNA, phosphorylated …
differentiation and mineralization of vascular smooth muscle cells (VSMC). In this study, we
examined the molecular mechanisms by which stearate promotes vascular calcification.
ATF4 is a pivotal transcription factor in osteoblastogenesis and endoplasmic reticulum (ER)
stress. Increased stearate by either supplementation of exogenous stearic acid or inhibition
of stearoyl-CoA desaturase (SCD) by CAY10566 induced ATF4 mRNA, phosphorylated …