[PDF][PDF] As a matter of fat
RT Brookheart, CI Michel, JE Schaffer - Cell metabolism, 2009 - cell.com
RT Brookheart, CI Michel, JE Schaffer
Cell metabolism, 2009•cell.comExcess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease.
When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-
response is elicited, characterized by destruction of organelle membranes, activation of
stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid
overload causes nonadipose cell death and contributes to the pathogenesis of obesity and
diabetes.
When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-
response is elicited, characterized by destruction of organelle membranes, activation of
stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid
overload causes nonadipose cell death and contributes to the pathogenesis of obesity and
diabetes.
Excess fatty acid accumulation in nonadipose tissues is a hallmark of metabolic disease. When elevated lipid levels exceed the cell's capacity to store or utilize fatty acids, a lipotoxic-response is elicited, characterized by destruction of organelle membranes, activation of stress pathways, and apoptosis. This Minireview focuses on the mechanisms by which lipid overload causes nonadipose cell death and contributes to the pathogenesis of obesity and diabetes.
cell.com