[HTML][HTML] Increased lipogenesis and stearate accelerate vascular calcification in calcifying vascular cells

TC Ting, S Miyazaki-Anzai, M Masuda, M Levi… - Journal of Biological …, 2011 - ASBMB
Vascular calcification is recognized as an independent predictor of cardiovascular mortality,
particularly in subjects with chronic kidney disease. However, the pathways by which
dysregulation of lipid and mineral metabolism simultaneously occur in this particular
population remain unclear. We have shown that activation of the farnesoid X receptor (FXR)
blocks mineralization of bovine calcifying vascular cells (CVCs) and in ApoE knock-out mice
with 5/6 nephrectomy. In contrast to FXR, this study showed that liver X receptor (LXR) …