The role of transforming growth factor beta in atherosclerosis: novel insights and future perspectives
Z Mallat, A Tedgui - Current opinion in lipidology, 2002 - journals.lww.com
Z Mallat, A Tedgui
Current opinion in lipidology, 2002•journals.lww.comTransforming growth factor beta is identified as a critical modulator of the immuno-
inflammatory balance in atherosclerosis, and a crucial plaque-stabilizing factor. Future
studies should aim at defining the precise molecular mechanisms responsible for this
protective effect, and developing immunomodulatory strategies based on the promotion of
transforming growth factor beta activity (T regulatory T helper type 3 cells) to limit disease
complications.
inflammatory balance in atherosclerosis, and a crucial plaque-stabilizing factor. Future
studies should aim at defining the precise molecular mechanisms responsible for this
protective effect, and developing immunomodulatory strategies based on the promotion of
transforming growth factor beta activity (T regulatory T helper type 3 cells) to limit disease
complications.
Summary
Transforming growth factor beta is identified as a critical modulator of the immuno-inflammatory balance in atherosclerosis, and a crucial plaque-stabilizing factor. Future studies should aim at defining the precise molecular mechanisms responsible for this protective effect, and developing immunomodulatory strategies based on the promotion of transforming growth factor beta activity (T regulatory T helper type 3 cells) to limit disease complications.
Lippincott Williams & Wilkins