The regulation of synthesis, degradation, and distribution of lipids is crucial for homeostasis
of organisms and cells. The sterol regulatory element-binding protein (SREBP) transcription
factor family is post-translationally activated in situations of reduced lipid abundance and
activates numerous genes involved in cholesterol, fatty acid, and phospholipid synthesis. In
this study, we provide evidence that the primary transcript of SREBP2 contains an intronic
miRNA (miR-33) that reduces cellular cholesterol export via inhibition of translation of the …