Aging of the hematopoietic system
HW Snoeck - Current opinion in hematology, 2013 - journals.lww.com
HW Snoeck
Current opinion in hematology, 2013•journals.lww.comWe argue that age-related changes in HSCs and in the hematopoietic system may not
entirely be due to a degenerative aging process, but are the result of developmental and
stem cell-protective mechanisms aimed at maximizing fitness during reproductive life. These
mechanisms may be disadvantageous later in life as damaged HSCs accumulate and
establishment of responses to neoantigens becomes compromised because of the reduced
generation of naive T and B cells.
entirely be due to a degenerative aging process, but are the result of developmental and
stem cell-protective mechanisms aimed at maximizing fitness during reproductive life. These
mechanisms may be disadvantageous later in life as damaged HSCs accumulate and
establishment of responses to neoantigens becomes compromised because of the reduced
generation of naive T and B cells.
Summary
We argue that age-related changes in HSCs and in the hematopoietic system may not entirely be due to a degenerative aging process, but are the result of developmental and stem cell-protective mechanisms aimed at maximizing fitness during reproductive life. These mechanisms may be disadvantageous later in life as damaged HSCs accumulate and establishment of responses to neoantigens becomes compromised because of the reduced generation of naive T and B cells.
Lippincott Williams & Wilkins