Prostaglandins and renin release: I. Stimulation of renin release from rabbit renal cortical slices by PGI2
AR Whorton, K Misono, J Hollifield, JC Frolich… - Prostaglandins, 1977 - Elsevier
Prostaglandins have been shown to be involved in the mechanism of renin secretion in a
variety of situations. Both arachidonic acid and prostaglandin endoperoxide have been
shown to release renin from cortical slices and to be converted to PGI 2 by cortical
microsomes. In the present studies PGI 2 was found to cause a time dependent increase in
renin release from rabbit renal cortical slices, a system isolated from any indirect effects that
result from the administration of prostaglandins in vivo. The stimulation was linear up to 30 …
variety of situations. Both arachidonic acid and prostaglandin endoperoxide have been
shown to release renin from cortical slices and to be converted to PGI 2 by cortical
microsomes. In the present studies PGI 2 was found to cause a time dependent increase in
renin release from rabbit renal cortical slices, a system isolated from any indirect effects that
result from the administration of prostaglandins in vivo. The stimulation was linear up to 30 …