Importance Glioblastoma is the most common primary malignant brain tumor, but despite
multimodal treatment with surgery, radiotherapy, and temozolomide chemotherapy, the
prognosis is poor, with a median survival of 16 to 19 months and poor quality of life
throughout the disease course. New treatments are needed. Evidence Review Articles were
identified through a search of PubMed references from March 2005 through January 2014,
using the termsglioblastoma, glioma, malignant glioma, andbrain neoplasm, as well as by …