[HTML][HTML] The microtubule-associated histone deacetylase 6 (HDAC6) regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation
Y Gao, CC Hubbert, TP Yao - Journal of Biological Chemistry, 2010 - ASBMB
Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase with tubulin
deacetylase activity, and it binds dynein motors. Recent studies revealed that microtubule
acetylation affects the affinity and processivity of microtubule motors. These unique
properties implicate a role for HDAC6 in intracellular organelle transport. Here, we show that
HDAC6 associates with the endosomal compartments and controls epidermal growth factor
receptor (EGFR) trafficking and degradation. We found that loss of HDAC6 promoted EGFR …
deacetylase activity, and it binds dynein motors. Recent studies revealed that microtubule
acetylation affects the affinity and processivity of microtubule motors. These unique
properties implicate a role for HDAC6 in intracellular organelle transport. Here, we show that
HDAC6 associates with the endosomal compartments and controls epidermal growth factor
receptor (EGFR) trafficking and degradation. We found that loss of HDAC6 promoted EGFR …