[HTML][HTML] Bidirectional signaling between sarcoglycans and the integrin adhesion system in cultured L6 myocytes
T Yoshida, Y Pan, H Hanada, Y Iwata… - Journal of Biological …, 1998 - ASBMB
The rat L6 skeletal muscle cell line was used to study expression of the dystrophin-
containing glycoprotein complex and its interaction with the integrin system involved in the
cell-matrix adhesion reaction. A complex of dystrophin and its associated proteins was fully
expressed in L6 myotubes, from which anti-dystrophin or anti-α-sarcoglycan co-precipitated
integrin α 5 β 1 and other focal adhesion-associated proteins vinculin, talin, paxillin, and
focal adhesion kinase. Immunostaining and confocal microscopy revealed that dystrophin, α …
containing glycoprotein complex and its interaction with the integrin system involved in the
cell-matrix adhesion reaction. A complex of dystrophin and its associated proteins was fully
expressed in L6 myotubes, from which anti-dystrophin or anti-α-sarcoglycan co-precipitated
integrin α 5 β 1 and other focal adhesion-associated proteins vinculin, talin, paxillin, and
focal adhesion kinase. Immunostaining and confocal microscopy revealed that dystrophin, α …