Localization of NK1. 1+ invariant Vα19 TCR+ cells in the liver with potential to promptly respond to TCR stimulation
M Shimamura, YY Huang, R Migishima, M Yokoyama… - Immunology letters, 2008 - Elsevier
Previously, we found that more than a half of the NK1. 1+ T cell lines prepared from CD1−/−
livers expressed invariant Vα19-Jα33 TCR α chains. Over-expression of the invariant Vα19-
Jα33 TCR α transgene (Tg) with a natural TCR α promoter and an enhancer in mice induced
the development of NK1. 1+ T cells (Vα19 NKT cells) in the lymphoid organs, especially in
the liver. Preferential usage of the Vα19 Tg by NKT cells in the transgenic mouse livers was
indirectly indicated by the observation that few NK1. 1+ TCRαβ+ cells of the Vα19 Tg livers …
livers expressed invariant Vα19-Jα33 TCR α chains. Over-expression of the invariant Vα19-
Jα33 TCR α transgene (Tg) with a natural TCR α promoter and an enhancer in mice induced
the development of NK1. 1+ T cells (Vα19 NKT cells) in the lymphoid organs, especially in
the liver. Preferential usage of the Vα19 Tg by NKT cells in the transgenic mouse livers was
indirectly indicated by the observation that few NK1. 1+ TCRαβ+ cells of the Vα19 Tg livers …