[HTML][HTML] Apoptotic cells, through transforming growth factor-β, coordinately induce anti-inflammatory and suppress pro-inflammatory eicosanoid and NO synthesis in …

CG Freire-de-Lima, YQ Xiao, SJ Gardai… - Journal of Biological …, 2006 - ASBMB
Apoptotic cells are rapidly engulfed by adjacent tissue cells or macrophages before they can
release pro-inflammatory/proimmunogenic intracellular contents. In addition, recognition of
the apoptotic cells is actively anti-inflammatory and anti-immunogenic with generation of anti-
inflammatory mediators such as transforming growth factor-β (TGF-β) and anti-inflammatory
eicosanoids. Here, we have investigated the role played by the induction of TGF-β in the
coordinate expression of anti-inflammatory eicosanoids or peroxisome proliferator-activated …