[HTML][HTML] A nibbling mechanism for clathrin-mediated retrieval of secretory granule membrane after exocytosis
MA Bittner, RL Aikman, RW Holz - Journal of Biological Chemistry, 2013 - ASBMB
Clathrin-mediated endocytosis is the major pathway for recycling of granule membrane
components after strong stimulation and high exocytotic rates. It resembles" classical"
receptor-mediated endocytosis but has a trigger that is unique to secretion, the sudden
appearance of the secretory granule membrane in the plasma membrane. The spatial
localization, the relationship to individual fusion events, the nature of the cargo, and the
timing and nature of the nucleation events are unknown. Furthermore, a size mismatch …
components after strong stimulation and high exocytotic rates. It resembles" classical"
receptor-mediated endocytosis but has a trigger that is unique to secretion, the sudden
appearance of the secretory granule membrane in the plasma membrane. The spatial
localization, the relationship to individual fusion events, the nature of the cargo, and the
timing and nature of the nucleation events are unknown. Furthermore, a size mismatch …