Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line
HP Gaeggeler, E Gonzalez-Rodriguez… - Journal of the …, 2005 - journals.lww.com
Aldosterone controls sodium balance by regulating an epithelial sodium channel (ENaC)-
mediated sodium transport along the aldosterone-sensitive distal nephron, which expresses
both mineralocorticoid (MR) and glucocorticoid receptors (GR). Mineralocorticoid specificity
is ensured by 11β-hydroxysteroid dehydrogenase type 2, which metabolizes cortisol or
corticosterone into inactive metabolites that are unable to bind MR and/or GR. The fractional
occupancy of MR and GR by aldosterone mediating the sodium transport response in the …
mediated sodium transport along the aldosterone-sensitive distal nephron, which expresses
both mineralocorticoid (MR) and glucocorticoid receptors (GR). Mineralocorticoid specificity
is ensured by 11β-hydroxysteroid dehydrogenase type 2, which metabolizes cortisol or
corticosterone into inactive metabolites that are unable to bind MR and/or GR. The fractional
occupancy of MR and GR by aldosterone mediating the sodium transport response in the …