MicroRNA-29a promotion of nephrin acetylation ameliorates hyperglycemia-induced podocyte dysfunction
CL Lin, PH Lee, YC Hsu, CC Lei, JY Ko… - Journal of the …, 2014 - journals.lww.com
Podocyte dysfunction is a detrimental feature in diabetic nephropathy, with loss of nephrin
integrity contributing to diabetic podocytopathy. MicroRNAs (miRs) reportedly modulate the
hyperglycemia-induced perturbation of renal tissue homeostasis. This study investigated
whether regulation of histone deacetylase (HDAC) actions and nephrin acetylation by miR-
29 contributes to podocyte homeostasis and renal function in diabetic kidneys.
Hyperglycemia accelerated podocyte injury and reduced nephrin, acetylated nephrin, and …
integrity contributing to diabetic podocytopathy. MicroRNAs (miRs) reportedly modulate the
hyperglycemia-induced perturbation of renal tissue homeostasis. This study investigated
whether regulation of histone deacetylase (HDAC) actions and nephrin acetylation by miR-
29 contributes to podocyte homeostasis and renal function in diabetic kidneys.
Hyperglycemia accelerated podocyte injury and reduced nephrin, acetylated nephrin, and …