Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury
J Ho, KH Ng, S Rosen, A Dostal… - Journal of the …, 2008 - journals.lww.com
MicroRNAs (miRNAs) are in a class of endogenous, small, noncoding RNAs that exert their
effects through posttranscriptional repression of specific target mRNAs. Although miRNAs
have been implicated in the regulation of diverse biologic processes, little is known about
miRNA function in the kidney. Here, mice lacking functional miRNAs in the developing
podocyte were generated through podocyte-specific knockout of Dicer, an enzyme required
for the production of mature miRNAs (Nphs2-Cre; Dicer flx/flx). Podocyte-specific loss of …
effects through posttranscriptional repression of specific target mRNAs. Although miRNAs
have been implicated in the regulation of diverse biologic processes, little is known about
miRNA function in the kidney. Here, mice lacking functional miRNAs in the developing
podocyte were generated through podocyte-specific knockout of Dicer, an enzyme required
for the production of mature miRNAs (Nphs2-Cre; Dicer flx/flx). Podocyte-specific loss of …