[HTML][HTML] SUMOylation of Pancreatic Glucokinase Regulates Its Cellular Stability and Activity*[S]

I Aukrust, L Bjørkhaug, M Negahdar, J Molnes… - Journal of Biological …, 2013 - ASBMB
Glucokinase is the predominant hexokinase expressed in hepatocytes and pancreatic β-
cells, with a pivotal role in regulating glucose-stimulated insulin secretion, illustrated by
glucokinase gene mutations causing monogenic diabetes and congenital hyperinsulinemic
hypoglycemia. A complex tissue-specific network of mechanisms regulates this enzyme, and
a major unanswered question in glucokinase biology is how post-translational modifications
control the function of the enzyme. Here, we show that the pancreatic isoform of human …