Impaired in vitro regulatory T cell function associated with Wiskott–Aldrich syndrome
M Adriani, J Aoki, R Horai, AM Thornton, A Konno… - Clinical …, 2007 - Elsevier
Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency characterized by the
contradictory coexistence of impaired T-cell function and exaggerated T-cell-mediated
pathology, including autoimmunity and eczema. WAS protein (WASp)-deficient mice are
also immunodeficient and can develop autoimmune disease. Since defects in regulatory T-
cells (Treg) are associated with autoimmunity, we examined the presence and function of
these cells in WAS patients and WASp-deficient mice. We found that CD4+ CD25+ FOXP3+ …
contradictory coexistence of impaired T-cell function and exaggerated T-cell-mediated
pathology, including autoimmunity and eczema. WAS protein (WASp)-deficient mice are
also immunodeficient and can develop autoimmune disease. Since defects in regulatory T-
cells (Treg) are associated with autoimmunity, we examined the presence and function of
these cells in WAS patients and WASp-deficient mice. We found that CD4+ CD25+ FOXP3+ …