Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis: a randomized controlled trial
JC Tardif, J Grégoire, PL L'Allier, R Ibrahim… - Jama, 2007 - jamanetwork.com
ContextHigh-density lipoprotein (HDL) cholesterol is an inverse predictor of coronary
atherosclerotic disease. Preliminary data have suggested that HDL infusions can induce
atherosclerosis regression. ObjectiveTo investigate the effects of reconstituted HDL on
plaque burden as assessed by intravascular ultrasound (IVUS). Design and SettingA
randomized placebo-controlled trial was conducted at 17 centers in Canada. Intravascular
ultrasound was performed to assess coronary atheroma at baseline and 2 to 3 weeks after …
atherosclerotic disease. Preliminary data have suggested that HDL infusions can induce
atherosclerosis regression. ObjectiveTo investigate the effects of reconstituted HDL on
plaque burden as assessed by intravascular ultrasound (IVUS). Design and SettingA
randomized placebo-controlled trial was conducted at 17 centers in Canada. Intravascular
ultrasound was performed to assess coronary atheroma at baseline and 2 to 3 weeks after …