PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
BC Suh, B Hille - Annu. Rev. Biophys., 2008 - annualreviews.org
BC Suh, B Hille
Annu. Rev. Biophys., 2008•annualreviews.orgPhosphatidylinositol 4, 5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet
of plasma membranes. Many plasma membrane ion channels and ion transporters require
PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review
discusses the dependence of ion channels on phosphoinositides and considers possible
mechanisms by which PIP2 and analogues regulate ion channel activity.
of plasma membranes. Many plasma membrane ion channels and ion transporters require
PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review
discusses the dependence of ion channels on phosphoinositides and considers possible
mechanisms by which PIP2 and analogues regulate ion channel activity.
Phosphatidylinositol 4,5-bisphosphate (PIP2) is a minority phospholipid of the inner leaflet of plasma membranes. Many plasma membrane ion channels and ion transporters require PIP2 to function and can be turned off by signaling pathways that deplete PIP2. This review discusses the dependence of ion channels on phosphoinositides and considers possible mechanisms by which PIP2 and analogues regulate ion channel activity.
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