Gluconeogenesis contributes to insulin resistance in type 1 and type 2 diabetes, but its
regulation and the underlying molecular mechanisms remain unclear. Recently, calcium-
regulated heat-stable protein 1 (CARHSP1) was identified as a biomarker for diabetic
complications. In this study, we investigated the role of CARHSP1 in hepatic
gluconeogenesis. We assessed the regulation of hepatic CARHSP1 expression under
conditions of fasting and refeeding. Adenovirus-mediated CARHSP1 overexpression and …