Two striking facts surround the practice of vaccination: It is the sole medical approach to
have fully annihilated a disease, yet the development of most effective vaccines took place
without considering the intricate cellular processes they wish to effectuate. While extremely
potent vaccines have been developed that can protect practically a lifetime after a single
dose, numerous other vaccines have utterly failed or provide only marginal protection. Here,
we aim to illustrate why this difference in efficacy exists, and underline why specific cytotoxic …