Suppression of antigen presentation by IL-10

SK Mittal, PA Roche - Current opinion in immunology, 2015 - Elsevier
SK Mittal, PA Roche
Current opinion in immunology, 2015Elsevier
Highlights•IL-10 inhibits T cell activation by suppressing APC function.•IL-10 suppresses
TLR-signaling in dendritic cells and monocytes/macrophages.•IL-10 suppresses IFNγ-
signaling in monocytes/macrophages.•IL-10 stimulates expression of the E3 ligase March-I
in monocytes/macrophages.Regulated antigen presentation to immune cells determines the
effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that
regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in …
Highlights
  • IL-10 inhibits T cell activation by suppressing APC function.
  • IL-10 suppresses TLR-signaling in dendritic cells and monocytes/macrophages.
  • IL-10 suppresses IFNγ-signaling in monocytes/macrophages.
  • IL-10 stimulates expression of the E3 ligase March-I in monocytes/macrophages.
Regulated antigen presentation to immune cells determines the effectiveness of an immune response. IL-10 is an immunosuppressive cytokine that regulates immune responses by inhibiting the ability of APCs to present antigens to T cells in a variety of ways. The mechanisms of IL-10-mediated immunosuppression include interference in TLR-mediated or IFNγ-mediated dendritic cell (DC) and macrophage activation as well as direct induction of genes that suppress APC function. In this review we will discuss current studies exploring the molecular mechanisms by which IL-10 suppresses APC function.
Elsevier