Cyclophosphamide-induced suppressor cells in mice: suppression of the antibody response in vitro and characterization of the effector cells
M Segre, E Tomei, D Segre - Cellular immunology, 1985 - Elsevier
It was found earlier that nonspecific suppressor cells obtained from the spleen of mice
injected with cyclophosphamide (Cy) at a dose of 200 mg/kg body wt are nonadherent,
surface Ig negative, and Thy-1 negative. It is now reported that Cy-induced suppressor (Cy-
S) cells suppress the in vitro primary and secondary humoral responses in a dose-
dependent manner. Suppressor activity is a property of a low density cell that is found in the
spleen from 5 to 11 days after Cy administration. Cy-S cells are negative for a number of T …
injected with cyclophosphamide (Cy) at a dose of 200 mg/kg body wt are nonadherent,
surface Ig negative, and Thy-1 negative. It is now reported that Cy-induced suppressor (Cy-
S) cells suppress the in vitro primary and secondary humoral responses in a dose-
dependent manner. Suppressor activity is a property of a low density cell that is found in the
spleen from 5 to 11 days after Cy administration. Cy-S cells are negative for a number of T …