Association of myeloid-derived suppressor cells and efficacy of cytokine-induced killer cell immunotherapy in metastatic renal cell carcinoma patients
Z Wang, Y Zhang, Y Liu, L Wang, L Zhao… - Journal of …, 2014 - journals.lww.com
Metastatic renal cell carcinoma (MRCC) is one of the malignancies that are sensitive to
immunotherapy. However, the underlying immune inhibitory factors such as myeloid-derived
suppressor cells (MDSCs) might restrain the efficacy of immunotherapy. The present study
investigates the clinical efficacy of cytokine-induced killer (CIK) cell therapy in patients with
MRCC and explores whether the levels of peripheral MDSCs are associated with the
prognosis of patients receiving this therapy. Twenty-nine patients with measurable MRCC …
immunotherapy. However, the underlying immune inhibitory factors such as myeloid-derived
suppressor cells (MDSCs) might restrain the efficacy of immunotherapy. The present study
investigates the clinical efficacy of cytokine-induced killer (CIK) cell therapy in patients with
MRCC and explores whether the levels of peripheral MDSCs are associated with the
prognosis of patients receiving this therapy. Twenty-nine patients with measurable MRCC …